{"id":1146,"date":"2024-07-04T13:42:30","date_gmt":"2024-07-04T11:42:30","guid":{"rendered":"https:\/\/www.sys2diag.cnrs.fr\/?page_id=1146"},"modified":"2024-07-04T14:59:49","modified_gmt":"2024-07-04T12:59:49","slug":"clinical-proteomics-platform-2","status":"publish","type":"page","link":"https:\/\/www.sys2diag.cnrs.fr\/en\/platforms\/clinical-proteomics-platform-2\/","title":{"rendered":"Clinical Proteomics Platform"},"content":{"rendered":"

\"\"<\/p>\n

Platform managers:<\/b><\/h3>\n

Technical manager and coordinator | Laurence MOLINA<\/b>
\nScientific manager | Franck MOLINA<\/b><\/p>\n

\n

Request for Services : <\/b><\/h3>\n

Request for service: To ask for prestation you can send an e.mail to : ppc[@]sys2diag.cnrs.fr or complete the form on this page.<\/p>\n

By clicking here <\/span><\/a>> Access the service request form<\/h3>\n
\n

Missions : <\/b><\/h3>\n

The Clinical Proteomics Platform (PPC) aims to exploit the latest technological and bioinformatic developments in proteomics for the discovery and validation of biomarkers in complex human pathologies.
\nThe missions set for the clinical proteomics platform revolve around 2 axes:
\n– Develop new methodological approaches for clinical proteomics in the field of preparation of biological samples (pre-fractionation, enrichment in low abundance proteins, …), protein separation and bioinformatic analysis of data.
\n– Make available to regional academic and industrial teams and beyond, medical, biological and technical expertise in Clinical Proteomics.<\/p>\n

\n

Skills : <\/b><\/h3>\n

Biochemistry <\/b>
\n\u25cf Help in the design of proteomic experiments
\n\u25cf Preparation of biological samples for proteomic analysis (pre-fractionation, protein enrichment, …)
\n\u25cf Separation of proteins by electrophoresis (1D and 2D)
\n\u25cf Image analysis (Progenesis Samespot, Sili2Dgel)
\n\u25cf Quantitative and qualitative proteomics
\n\u25cf Multiplexed dosages<\/p>\n

Biostatistics \/ Bioinformatics <\/b>
\n\u25cf Data management: Data quality control, identification of biases, preliminary data processing (normalization, subtraction of background noise)
\n\u25cf Functional analyzes of biological protein networks<\/p>\n

Peptides arrays – interaction analysis <\/b>
\n\u25cf Rapid synthesis of a large number of different peptides on a cellulose membrane (arrays peptide) for the mapping and characterization of epitopes and interaction sites. The reactivity is easily evaluated by tests of the immuno-revelation type.<\/p>\n

Microfluidics <\/b>
\n\u25cf Plate of microfluidic analyzes in homogeneous and heterogeneous phases (droplets, vesicles, cells)<\/p>\n

\n

Equipements : <\/b><\/h3>\n

\u25cf Separation of proteins in mono and two-dimensional gel and image analysis (MS Access)
\n\u25cf Multiplexed analysis of luminex\u00ae type (Bioplex\u00ae, Biorad)
\n\u25cf Software in biostatistics, network analysis and mathematics: R, Cytoscape
\n\u25cf Computing and storage servers.
\n\u25cf Multipep synthesis robot (Intavis)
\n\u25cf Microfluidic analysis system (fluorescence microscope, lasers, micro-pumps, high speed cameras, etc.)<\/p>\n

\n

Access : <\/b><\/h3>\n

The platform welcomes laboratory projects but also projects of academic or private research teams in the form of collaborations (or services). The Platform offers expertise and technical resources in biochemistry, biostatistics, bioinformatics, microfluidics and peptide chemistry applied to the fields of clinical proteomics.<\/p>\n

\n

Quality : <\/b><\/h3>\n

In order to fully subscribe to the quality criteria and plateform has embarked on a quality approach.<\/p>\n","protected":false},"excerpt":{"rendered":"

Platform managers: Technical manager and coordinator | Laurence MOLINA Scientific manager | Franck MOLINA Request for Services : Request for service: To ask for prestation you can send an e.mail …<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":799,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1146","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/1146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/comments?post=1146"}],"version-history":[{"count":6,"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/1146\/revisions"}],"predecessor-version":[{"id":1175,"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/1146\/revisions\/1175"}],"up":[{"embeddable":true,"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/pages\/799"}],"wp:attachment":[{"href":"https:\/\/www.sys2diag.cnrs.fr\/en\/wp-json\/wp\/v2\/media?parent=1146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}